For the injection of lines or wrinkles, treatment involves some discomfort, and an anaesthetic cream may be applied an hour beforehand. With regards to the treatment of the lips, a local anaesthetic injection is usually used to numb the area.

The procedure generally takes around 30 minutes with the effect usually lasting between 6 months to a year but is extremely variable. Due to variations in the individual response and the degree of fullness desired, the effect is often assessed at 3 to 4 weeks post treatment. Further injection may be undergone at this stage.